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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAICS All Species: 48.48
Human Site: T105 Identified Species: 88.89
UniProt: P22234 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22234 NP_001072992.1 425 47079 T105 W V C R R I A T G S F L K R N
Chimpanzee Pan troglodytes XP_001140521 451 49634 T131 W V C R R I A T G S F L K R N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532381 425 46974 T105 W V C R R I A T G S F L K R N
Cat Felis silvestris
Mouse Mus musculus Q9DCL9 425 47052 T105 W V C R R I A T G S F L K R N
Rat Rattus norvegicus P51583 425 47078 T105 W V C R R I A T G S F L K R N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516499 348 38076 D60 K V E L F F K D D A N N D P Q
Chicken Gallus gallus P38024 426 47222 T106 W V C R R I A T G S F L K R N
Frog Xenopus laevis NP_001080163 425 47148 T105 W V C R R I A T G S F L K R N
Zebra Danio Brachydanio rerio NP_955831 425 47059 T105 W V C R R I A T G S F L K R N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9I7S8 429 47263 T110 W V T R R L A T G S F L K R N
Honey Bee Apis mellifera XP_624351 420 47251 T102 W V T R R L A T G S F L K R Y
Nematode Worm Caenorhab. elegans Q10457 423 46959 T109 W V A R R V A T G S F L K R N
Sea Urchin Strong. purpuratus XP_780342 419 46499 T99 W V T R R V A T G S F L K R N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.1 N.A. 96.4 N.A. 95 96.2 N.A. 61.6 85.6 81.4 78.3 N.A. 58.7 54.5 49.6 62.1
Protein Similarity: 100 94 N.A. 98.3 N.A. 99.5 99 N.A. 69.6 92.4 90.3 91.7 N.A. 73.6 70.8 68.2 76
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 100 100 100 N.A. 86.6 80 86.6 86.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 13.3 100 100 100 N.A. 93.3 86.6 93.3 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 93 0 0 8 0 0 0 0 0 % A
% Cys: 0 0 62 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 8 0 0 0 8 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 8 0 0 0 0 93 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 93 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 62 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 8 0 0 0 0 0 93 0 0 % K
% Leu: 0 0 0 8 0 16 0 0 0 0 0 93 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 85 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 0 0 0 93 93 0 0 0 0 0 0 0 0 93 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 93 0 0 0 0 0 % S
% Thr: 0 0 24 0 0 0 0 93 0 0 0 0 0 0 0 % T
% Val: 0 100 0 0 0 16 0 0 0 0 0 0 0 0 0 % V
% Trp: 93 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _